Answered by: Richard Alan Miller
Question from: Towanna
Posted on: March 16, 2002

What is synephrine and what are the effects on the body, good and bad?

Synephrine is the primary chemistry of the bitter orange, grown mostly in China and some regions of Europe. It is a CNS stimulant, but does not give the so-called "speed-rush" as when taking such stimulants as ephedrine sulphate (Mormon Tea). Less than 25% goes across the blood-brain barrier.

Most of it (75%) goes to the Beta-3 site in the gut, primarily burning fat. To my knowledge very little study has been made on this chemistry, although it has been used for centuries as a weight-reducing agent. What does exist is generally non-toxic, with no GRAS ruling. Bitter orange does have known distinct phototoxic activity, so the physical handling of it is important.

Synephrine is an adrenergic amine that enhances the metabolic rate, increases fat burning and spares muscle protein. Derived from Citrus aurantium, it is a natural alternative to ephedrine, providing maximum weight-loss results without the side effects of Ephedra. Synephrine binds with the Beta 3 cell receptors to increase the rate at which fat is released from body stores (lipolysis), along with increasing the metabolic rate.

It offers all of the advantages of a stimulant, without the drawbacks. Weight loss clinics throughout the USA are now reporting improved rates of weight loss while using Synephrine without the side effects of ephedrine. Clients have reported up to a 42% reduction in total body fat after using Synephrine.

I have written a feature article on this new product, but have not yet published it.

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